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Regulation of prostanoid-synthesis in the cardiovascular system
R M Nüsing1, T Klein, I Siegle
1Faculty of Biology, University of Konstanz, FRG.
Agents and Actions. Supplements
|January 1, 1995
Abstract:
Thromboxane A2 and prostacyclin are the two prostanoids involved in the regulation of the vascular tone. Their release is controlled by the activity of cyclooxygenase which has made this enzyme a preferred pharmacological target. We here report on the distribution of the two isoforms of cyclooxygenase in cultured mesangial cells and on a selective inhibitor of the cytokine-inducible cyclooxygenase-2. We also comment on the structure of thromboxane and prostacyclin synthase and their regulation under physiological and pathophysiological conditions.