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Postoperative neuroleptic malignant syndrome

A Shaw¹, E E Matthews

¹Anaesthetic Department, North Staffordshire Royal Infirmary, Hartshill, Stoke-on-Trent.

|March 1, 1995

Summary

Neuroleptic malignant syndrome (NMS) occurred in a child after medication. Prompt treatment with dantrolene sodium and forced alkaline diuresis led to complete recovery, highlighting effective NMS management strategies.

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Area of Science:

Pediatric Neurology
Clinical Toxicology
Pharmacology

Background:

Neuroleptic Malignant Syndrome (NMS) is a rare but life-threatening reaction to antipsychotic medications.
Previous healthy pediatric patients are susceptible to NMS.
Hyponatremia can be a potential precipitating factor in NMS development.

Observation:

A previously healthy 6-year-old child developed NMS.
The child had been administered droperidol and metoclopramide.
Hyponatremia was suspected as a contributing factor.

Findings:

The patient presented with classic symptoms of NMS.
Treatment involved dantrolene sodium and forced alkaline diuresis.
The child experienced a full recovery.

Implications:

This case highlights the importance of recognizing NMS in pediatric patients.
Early and aggressive treatment is crucial for favorable outcomes in NMS.
Understanding potential precipitating factors like hyponatremia can aid in prevention and management.

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