Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Basal cell proliferation in benign prostatic hyperplasia

G B Dermer

    Cancer
    |May 1, 1978
    PubMed
    Summary

    Prostate basal cells, identified by toluidine blue staining, proliferate and may generate secretory cells in benign prostatic hyperplasia. This finding offers insights into prostate cell dynamics and regeneration.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Unusual acidic light chains in murine SLE serum.

    Clinical and experimental immunology·1984
    Same author

    Human cancer research.

    Science (New York, N.Y.)·1983
    Same author

    Synthesis of alpha 1-antichymotrypsin and alpha 1-acid glycoprotein by human breast epithelial cells.

    Cancer research·1982
    Same author

    Enhancement techniques for detecting trace and fluid-specific components in two-dimensional electrophoresis patterns.

    Clinical chemistry·1982
    Same author

    Origin of bronchioloalveolar carcinoma and peripheral bronchial adenocarcinoma.

    Cancer·1982
    Same author

    Autoradiography of cellular glycoproteins reveals histogenesis of bronchogenic adenocarcinomas.

    Cancer·1981

    Area of Science:

    • Urology
    • Cell Biology
    • Histology

    Background:

    • The human prostate contains basal and secretory cells within glandular acini.
    • These cell types exhibit distinct toluidine blue staining affinities.
    • Benign prostatic hyperplasia (BPH) presents alterations in these cellular arrangements.

    Purpose of the Study:

    • To investigate the cellular origins and proliferative capacity within hyperplastic prostate glands.
    • To determine if basal cells contribute to the secretory cell population in BPH.

    Main Methods:

    • Light microscopy with toluidine blue staining to differentiate cell types.
    • Ultrastructural analysis of cellular morphology.
    • Autoradiographic analysis of 3H-thymidine incorporation in organ cultures of hyperplastic prostate tissue.

    Main Results:

    • Basal cells show a strong affinity for toluidine blue, while secretory cells stain poorly.
    • In BPH, areas of secretory-like cells exhibit basal cell morphology and toluidine blue uptake.
    • Only basal cells demonstrated DNA synthesis (3H-thymidine incorporation) in hyperplastic prostate explants.

    Conclusions:

    • Prostate basal cells possess proliferative capabilities.
    • Basal cells are a potential source for secretory cells in the context of benign prostatic hyperplasia.
    • Understanding basal cell proliferation is key to comprehending prostate gland dynamics in BPH.

    Related Experiment Videos