Reactivity and the fate of some composite bioimplants based on collagen in connective tissue

Three composite materials based on collagen gel prepared with ISC40 and supplemented with the tripeptide glycine-histidine-lysine (GHK) mixed with bioglass (BAS O), pure hydroxyapatite (grain: 0.5-1.0 microns and 13-23 microns) and shredded beef bone were tested in the laboratory rat and guinea-pig. In the course of 49 d, no signs of infectious inflammation or incompatibility were observed around subcutaneously installed bioimplants. Particles of glass and hydroxyapatite became subject to phagocytosis. Bone fragments were completely resorbed, and no signs of osteogenic activity were detected in the neighbourhood.