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Graves' hyperthyroidism following transient thyrotoxicosis during interferon therapy for chronic hepatitis type C
Internal Medicine (Tokyo, Japan)
|January 1, 1995
Summary
Long-term interferon (IFN) therapy for hepatitis C can induce Graves
Area of Science:
- Endocrinology
- Hepatology
- Immunology
Background:
- Interferon (IFN) therapy is a treatment for chronic active hepatitis C.
- Autoimmune conditions can be triggered or exacerbated by certain medical treatments.
Observation:
- A 52-year-old woman receiving 23 weeks of IFN-alpha for hepatitis C developed transient thyrotoxicosis.
- Thyroid-stimulating hormone (TSH)-receptor antibodies became positive post-IFN therapy, leading to Graves' hyperthyroidism.
Findings:
- This case demonstrates a sequential development of autoimmune hyperthyroidism during IFN therapy.
- The patient exhibited transient thyrotoxicosis, followed by TSH-receptor antibodies, and then Graves' disease.
Implications:
- This case offers insights into the pathogenesis of interferon-induced autoimmune hyperthyroidism.
- Understanding this mechanism may aid in managing patients undergoing IFN therapy.
- Highlights the potential for IFN to trigger autoimmune thyroid disorders.