Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

IgA anaphylactic transfusion reactions

S G Sandler1, D Mallory, D Malamut

  • 1National Reference Laboratory for Blood Group Serology American Red Cross Blood Services, Rockville, MD.

Transfusion Medicine Reviews
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rh immune globulin: an interfering substance in compatibility testing.

Immunohematology·2019
Same author

DEL phenotype.

Immunohematology·2017
Same author

Bloody Brilliant: A History of Blood Groups and Blood Groupers.

Immunohematology·2017
Same author

Immunosuppressive protocols for transplantation and certain hematologic malignancies can prevent the primary immune response to the D blood group antigen.

Immunohematology·2013
Same author

Education in transfusion medicine for medical students and doctors.

Vox sanguinis·2013
Same author

Laboratory methods for Rh immunoprophylaxis: a review.

Immunohematology·2011
Same journal

Assessment of CTLA-4, LAG-3, and TIM-3 Expression in Pediatric Patients With β-Thalassemia Major and Their Association With Alloimmunization.

Transfusion medicine reviews·2026
Same journal

A Reply to "Beyond Implementation: The Need for Validation, Equity, and Real-World Accountability in AI for Transfusion Medicine".

Transfusion medicine reviews·2026
Same journal

Beyond Implementation: The Need for Validation, Equity, and Real-World Accountability in AI for Transfusion Medicine.

Transfusion medicine reviews·2026
Same journal

Trust Over Knowledge: Rethinking Donor Iron Supplementation Strategies in Modern Blood Services-Authors' reply.

Transfusion medicine reviews·2026
Same journal

The Effect of Stress Ball and Music on Anxiety, Distress, and Pain Levels During Platelet Apheresis Donation: Randomized Controlled Trial.

Transfusion medicine reviews·2026
Same journal

Therapeutic Plateletpheresis for Thrombocytosis: Critical Analytic Reviews and Original Multicenter Experience.

Transfusion medicine reviews·2026
See all related articles

IgA anaphylactic transfusion reactions are rare. Testing for IgA antibodies using the PHA method in patients with suspected reactions is unreliable. Further research is needed for better risk prediction.

Area of Science:

  • Transfusion Medicine
  • Immunology
  • Allergy

Background:

  • Anaphylactic transfusion reactions due to IgA antibodies are infrequent but serious.
  • Clinical presentation of IgA anaphylaxis is indistinguishable from other anaphylactic causes.
  • Diagnosis relies on detecting IgA antibodies in patient serum, often using the PHA method.

Purpose of the Study:

  • To evaluate the diagnostic utility of the PHA method for detecting anti-IgA antibodies in suspected anaphylactic transfusion reactions.
  • To determine the prevalence of IgA deficiency and anti-IgA antibodies in blood donors.
  • To assess the reliability of anti-IgA detection for predicting transfusion reaction risk.

Main Methods:

  • Sera from patients with suspected IgA anaphylactic reactions were tested for IgA antibodies using the PHA method.

Related Experiment Videos

  • Serum IgA levels and anti-IgA antibodies were measured in blood donors using PHIA and PHA.
  • Prevalence of IgA deficiency and anti-IgA antibodies was calculated.

    • Main Results:

    • An IgA antibody was found in 76.3% of IgA-deficient patients but only 17.5% of all referred samples, suggesting other causes for suspected reactions.
    • The frequency of IgA deficiency and anti-IgA in blood donors was approximately 1 in 1,200.
    • Anti-IgA titers did not differentiate blood donors from patients with a history of anaphylactic transfusion reactions.

    Conclusions:

    • The PHA method for anti-IgA detection is not a reliable predictor of anaphylactic transfusion reaction risk.
    • The high prevalence of anti-IgA in blood donors compared to reaction frequency indicates a low predictive value.
    • More specific markers are required to identify individuals at risk for IgA-related transfusion reactions.