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Diastereomeric beta-lactam antibiotics. Analytical methods, isomerization and stereoselective pharmacokinetics
1Department of Pharmacokinetics and Biopharmaceutics, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
Journal of Chromatography. A
|March 3, 1995
Abstract:
Stereospecific HPLC methods for the determination of various diastereomeric beta-lactam antibiotics are reviewed. Stereoselectivity in the absorption, distribution and excretion of several diastereomeric beta-lactams is summarized. The isomerization of beta-lactam isomers and its influence on the pharmacokinetics and pharmacodynamics are discussed.