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Related Experiment Videos

Regulation and function of p21ras in T lymphocytes

M I Pastor1, M Woodrow, D Cantrell

  • 1Lymphocyte Activation Laboratory, Imperial Cancer Research Fund, London.

Cancer Surveys
|January 1, 1995
PubMed
Summary

p21ras is a critical signaling molecule in T cell activation, linking the T cell receptor (TCR) to downstream pathways that regulate Interleukin-2 (IL2) gene expression and T cell growth.

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Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Signaling

Background:

  • T cell activation by antigen stimulation leads to cytokine production and receptor expression.
  • Interleukin-2 (IL2) production and IL2 receptor acquisition are key events in mature T cell activation, directing T cell growth.
  • T cell receptor (TCR) signaling pathways regulate IL2 gene expression.

Purpose of the Study:

  • To review the role of p21ras in T cell activation signaling.
  • To elucidate how p21ras connects the TCR to intracellular kinase cascades.
  • To understand p21ras's control over IL2 gene transcription.

Main Methods:

  • Review of experimental data on T cell signaling pathways.
  • Analysis of the interaction between TCR, p21ras, Raf-1, ERK2, and NFAT.
  • Investigation of signaling pathways involving calcium/calcineurin.

Main Results:

  • The TCR regulates p21ras activity.
  • p21ras couples the TCR to the Raf-1/MAP kinase (ERK2) cascade.
  • p21ras controls a pathway cooperating with calcium/calcineurin to activate NFAT and stimulate IL2 gene expression.

Conclusions:

  • p21ras is a critical signaling molecule in immune cells.
  • p21ras plays a central role in linking TCR stimulation to IL2 production.
  • Understanding p21ras function is key to T cell activation research.

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