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Flow motion in peripheral diabetic neuropathy

S J Benbow1, D W Pryce, K Noblett

  • 1Department of Medicine, University of Liverpool, U.K.

Clinical Science (London, England : 1979)
|February 1, 1995
PubMed
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Diabetic peripheral neuropathy reduces cutaneous blood flow motion amplitude in the feet. This finding suggests that neurological control plays a role in regulating blood flow dynamics in individuals with diabetes.

Area of Science:

  • Vascular Physiology
  • Diabetology
  • Neurology

Background:

  • Cutaneous flow motion, the cyclical variation in blood flow, may be altered in diabetic neuropathy.
  • Previous research findings on this topic have been inconsistent.

Purpose of the Study:

  • To investigate the impact of diabetic peripheral neuropathy on the frequency and amplitude of cutaneous flow motion.
  • To compare flow motion characteristics between patients with diabetic neuropathy, diabetic patients without neuropathy, and healthy controls.

Main Methods:

  • Laser Doppler flowmetry was used to measure blood flow on the hands and feet of 12 patients with diabetic peripheral neuropathy, 10 diabetic patients without neuropathy, and 10 controls.
  • Fast Fourier Transform analysis was employed to analyze flow motion frequency and amplitude (0.05–0.2 Hz).

Related Experiment Videos

  • Peripheral neuropathy was diagnosed based on clinical history, examination, and peroneal nerve conduction velocities.

    • Main Results:

    • Flow motion frequency and amplitude in the hands were similar across all groups.
    • Flow motion frequency in the feet was also comparable between the three groups.
    • A significantly smaller relative amplitude of flow motion was observed in the feet of diabetic patients with neuropathy compared to those without neuropathy and controls (P < 0.02).

    Conclusions:

    • Diabetic peripheral neuropathy is associated with a reduced amplitude of cutaneous flow motion in the feet.
    • The findings suggest that neurological control mechanisms are involved in regulating the amplitude of flow motion.