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[Transient thyroid dysfunction during chronic viral hepatitis treated with alpha-interferon]

R Luboshitzky1, A Ayash, E Nussinson

  • 1Institute of Endocrinology, Central Emek Hospital, Afula.

Harefuah
|January 15, 1995
PubMed
Summary
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Alpha-interferon therapy can cause temporary thyroid dysfunction in patients with chronic viral hepatitis. Thyroid function normalized after discontinuing interferon, suggesting a transient effect.

Area of Science:

  • Endocrinology
  • Hepatology
  • Immunology

Background:

  • Chronic viral hepatitis requires treatment, often involving interferon therapies.
  • Thyroid function is crucial for overall health and can be affected by systemic treatments.
  • Autoimmune thyroid disease is a common endocrine disorder.

Observation:

  • Two patients with chronic viral hepatitis developed thyroid dysfunction during alpha-interferon treatment.
  • One patient experienced hypothyroidism, while the other developed hyperthyroidism.
  • These thyroid dysfunctions emerged months after initiating interferon therapy.

Findings:

  • Alpha-interferon treatment was associated with transient hypothyroidism and hyperthyroidism.
  • Thyroid function tests (TSH, FT4, T3) returned to normal within 1-2 months after stopping interferon.

Related Experiment Videos

  • Antimicrosomal antibodies were initially positive in the hypothyroid patient but became negative later.

    • Implications:

    • Alpha-interferon may induce temporary thyroid dysfunction in euthyroid patients.
    • Monitoring thyroid function during interferon therapy is advisable.
    • The transient nature of the dysfunction suggests a reversible mechanism of action.