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Thyroid autoimmunity and ageing

A Pinchera1, S Mariotti, G Barbesino

  • 1Istituto di Endocrinologia, University of Pisa, Italy.

Hormone Research
|January 1, 1995
PubMed
Summary
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Thyroid autoantibodies are common in the elderly but not necessarily due to aging itself. Their presence may indicate underlying age-associated diseases rather than being a direct consequence of the aging process.

Area of Science:

  • Gerontology
  • Immunology
  • Endocrinology

Background:

  • Aging is linked to increased serum autoantibodies, including thyroid autoantibodies.
  • The clinical significance of these thyroid autoantibodies in the elderly remains unclear.
  • Overt thyroid autoimmune diseases are not more prevalent in older adults, except for primary myxedema.

Purpose of the Study:

  • To investigate the relationship between thyroid autoantibodies, aging, and age-associated diseases.
  • To clarify whether thyroid autoimmunity is a consequence of aging or related to other conditions.

Main Methods:

  • Analysis of serum thyroid autoantibody prevalence in different elderly populations (healthy centenarians, selected aged groups, unselected/hospitalized elderly).
  • Comparison of autoantibody findings with clinical status, including subclinical hypothyroidism and overt thyroid disease.

Related Experiment Videos

  • Review of literature on the role of thyroid autoimmunity in age-associated disorders like coronary heart disease.

    • Main Results:

    • Thyroid autoantibodies are infrequent in healthy centenarians and highly selected aged individuals.
    • These autoantibodies are frequently found in unselected or hospitalized elderly populations.
    • A high prevalence of subclinical hypothyroidism exists in elderly individuals with positive thyroid autoantibodies.

    Conclusions:

    • Thyroid autoimmune phenomena are not a direct result of the aging process.
    • The presence of thyroid autoantibodies in the elderly may be associated with age-associated diseases.
    • Further research is needed to understand the link between thyroid autoimmunity and conditions like coronary heart disease in older adults.