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[Correlation between neonatal mortality and hyperinsulinema]

E Görbe1, J Hajdú, A Nobilis

  • 1Szülészeti és Nögyógyaszati Klinika, Semmelweis Orvostudományi Egyetem I.

Orvosi Hetilap
|April 9, 1995
PubMed
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Tight maternal blood glucose control is crucial for reducing neonatal complications. Umbilical cord insulin levels correlate with newborn morbidity, highlighting the need for careful diabetes management during pregnancy.

Area of Science:

  • Perinatology
  • Endocrinology
  • Neonatology

Background:

  • Maternal diabetes poses risks to neonatal health.
  • Effective blood glucose management during pregnancy is essential.
  • Neonatal morbidity is a significant concern in pregnancies complicated by diabetes.

Purpose of the Study:

  • To investigate the correlation between maternal diabetes severity, blood glucose control, and neonatal morbidity.
  • To assess the diagnostic value of umbilical cord insulin levels and cardiological ultrasound in predicting neonatal outcomes.

Main Methods:

  • Studied 115 newborns, including 40 with diabetic mothers.
  • Measured umbilical cord insulin levels.
  • Analyzed the relationship between maternal diabetes, glucose control, and neonatal morbidity.

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  • Evaluated the utility of cardiological ultrasound.

    • Main Results:

    • Significant differences in serum insulin levels were observed between low and high neonatal morbidity groups.
    • Maternal diabetes severity and blood glucose control impacted neonatal outcomes.
    • Umbilical cord insulin levels showed a correlation with neonatal morbidity.

    Conclusions:

    • Tight maternal blood glucose control is vital for decreasing neonatal morbidity.
    • Umbilical cord insulin levels may serve as a diagnostic marker for neonatal risk.
    • Cardiological ultrasound shows promise in identifying neonates at risk, aiding in morbidity reduction.