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[Antiphospholipid syndrome and the pneumologist]

J C Piette1, P Cacoub, M Karmochkine

  • 1Service de Médecine Interne, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.

Revue De Pneumologie Clinique
|January 1, 1994
PubMed
Summary

Antiphospholipid syndrome (APS) involves blood clots and pregnancy complications, often linked to autoimmune conditions. Respiratory issues like pulmonary embolism and hypertension are significant manifestations requiring long-term prevention strategies.

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Area of Science:

  • Rheumatology and Immunology
  • Cardiopulmonary Medicine

Context:

  • Antiphospholipid syndrome (APS) is characterized by thrombosis or pregnancy morbidity in the presence of antiphospholipid antibodies.
  • APS can occur secondary to systemic lupus erythematosus or as a primary condition.
  • Diverse and significant respiratory manifestations are associated with APS.

Purpose:

  • To detail the range of respiratory manifestations in Antiphospholipid Syndrome (APS).
  • To highlight the association between APS and various pulmonary complications.
  • To emphasize the importance of secondary prevention in APS management.

Summary:

  • APS commonly presents with venous or arterial thrombosis and/or pregnancy morbidity, linked to antiphospholipid antibodies.
  • Respiratory manifestations include frequent pulmonary embolism, pulmonary hypertension, and potential involvement in adult respiratory distress syndrome.

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  • Cardiac complications such as heart failure and myocardiopathy can also arise from APS.
  • Impact:

    • Understanding these respiratory and cardiac links is crucial for comprehensive APS diagnosis and patient care.
    • Highlights the need for vigilant monitoring and long-term secondary prevention strategies to reduce recurrent thrombosis in APS patients.
    • Contributes to the knowledge base for managing complex autoimmune disorders with multi-systemic implications.