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Tumor growth after laparotomy or laparoscopy. A preliminary study
J D Allendorf1, M Bessler, M L Kayton
1Department of Surgery, Columbia University, New York, NY 10032, USA.
Surgical Endoscopy
|January 1, 1995
Summary
Laparotomy, but not insufflation, promotes tumor growth in mice. This suggests surgical procedures may impact cancer progression, potentially due to immunosuppression, influencing cancer resection strategies.
Area of Science:
- Oncology
- Surgical Oncology
- Immunology
Background:
- Surgical interventions like laparotomy and insufflation are common in cancer care.
- The impact of these procedures on tumor establishment and growth requires further investigation.
Purpose of the Study:
- To compare the effects of laparotomy versus intraperitoneal insufflation on tumor establishment and growth in a murine model.
- To explore potential mechanisms, such as immunosuppression, underlying observed differences.
Main Methods:
- Female mice received intradermal inoculation of mouse mammary carcinoma cells.
- Mice were subjected to either laparotomy or intraperitoneal insufflation with carbon dioxide.
- Tumor growth and mass were monitored and measured post-procedure.
Main Results:
- Laparotomy significantly increased tumor establishment and growth compared to insufflation at both low and high tumor cell doses.
- Tumors in the laparotomy group were substantially larger by mass than in the insufflated group.
- No tumors grew in insufflated mice at postoperative day 14, while 70% of laparotomy mice developed tumors.
Conclusions:
- Laparotomy confers a permissive effect on tumor establishment and growth in this murine model.
- Peritoneal insufflation did not exhibit the same tumor-promoting effects as laparotomy.
- These findings suggest laparotomy-induced immunosuppression may facilitate tumor growth, impacting surgical approach selection for cancer resection.