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Digital image analysis of microcomedones
G E Piérard1, C Piérard-Franchimont, V Goffin
1Department of Dermatopathology, University of Liège, Belgium.
Objective:
Developing a technique for quantifying the number and size of follicular casts and microcomedones.
Background:
There is no human testing that is validated up to now to predict comedogenesis and comedolysis following topical applications of drugs or cosmetics.
Design:
Evaluations are performed by digital image analysis of cyanoacrylate follicular biopsies. The effects of two topical products are compared.
Results:
Microcomedogenesis was disclosed after a 2-month period of application of a cosmetic product aimed at treating acne. Microcomedolysis occurred following usage of a topical preparation containing benzoyl peroxide 5% and miconazole nitrate 2%.
Conclusion:
Digital image analysis of skin surface biopsies is a sensitive method documenting microcomedo formation and dissolution.