Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The Korsakoff syndrome

M D Kopelman1

  • 1Division of Psychiatry and Psychology, UMDS, Guy's Hospital, London.

The British Journal of Psychiatry : the Journal of Mental Science
|February 1, 1995
PubMed
Summary
This summary is machine-generated.

Korsakoff syndrome involves memory impairment due to thiamine depletion. Research highlights limbic/diencephalic circuits for new memory formation and frontal lobe dysfunction for retrograde memory loss.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The future of science publishing.

Cortex; a journal devoted to the study of the nervous system and behavior·2024
Same author

Long-term cognitive and psychiatric outcomes of acute respiratory distress syndrome managed with Extracorporeal Membrane Oxygenation.

Respiratory medicine·2021
Same author

HIV: ageing, cognition and neuroimaging at 4-year follow-up.

HIV medicine·2018
Same author

Psychologic/functional forms of memory disorder.

Handbook of clinical neurology·2016
Same author

Investigating virtual reality navigation in amnestic mild cognitive impairment using fMRI.

Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition·2015
Same author

Alterations in working memory networks in amnestic mild cognitive impairment.

Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition·2014

Area of Science:

  • Neuroscience
  • Neurology
  • Nutritional Science

Background:

  • Korsakoff syndrome research is expanding across disciplines.
  • This review synthesizes current findings on the syndrome's etiology and manifestations.

Observation:

  • Korsakoff syndrome is characterized by disproportionate memory impairment from thiamine depletion.
  • While often linked to alcoholism, non-alcoholic causes exist, though less common now.
  • Neuropathology shows widespread structural and metabolic abnormalities, especially in frontal lobes.

Findings:

  • The mammillary bodies, mammillo-thalamic tract, and anterior thalamus are critical for new memory formation.
  • Neurotransmitter depletions (cholinergic, glutamate/GABA, catecholamine, serotonergic) are under investigation.

Related Experiment Videos

  • Limbic/diencephalic circuits explain anterograde amnesia, while frontal lobe dysfunction likely causes retrograde memory loss.

    • Implications:

    • Understanding these circuits is key to addressing memory deficits in Korsakoff syndrome.
    • Further research is needed to clarify the role of neurotransmitter depletions and thiamine's precise impact.
    • This review provides a comprehensive overview for researchers and clinicians.