Related Experiment Videos
Host-range control of a retroviral disease: Friend erythroleukemia
1Divn of Hematology and Medical Oncology, Oregon Health Sciences University, Portland 97201-3098, USA.
Trends in Microbiology
|February 1, 1995
Abstract:
Since its discovery in 1957, Friend viral erythroleukemia has been the major model for understanding host genetic barriers to retroviral diseases and has facilitated the discovery of many polymorphic leukemia-control genes of mice. Some of these genes limit helper-virus replication, target-cell (erythroblast) pools or immune responses. At least one host gene appears to block the viral oncoprotein.