Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Pathophysiology of sleep]

A Steiger1

  • 1Max-Planck-Institut für Psychiatrie, Psychiatrische Klinik, München.

Praxis
|April 11, 1995
PubMed
Summary
This summary is machine-generated.

Disturbed sleep and decreased growth hormone secretion occur in aging and depression. Neuropeptides growth hormone-releasing hormone (GHRH) and corticotropin-releasing hormone (CRH) may regulate these sleep-endocrine changes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Non-Response to Antidepressants: Risk Factors and Therapeutic Possibilities.

Pharmacopsychiatry·2026
Same author

Development of Superconducting On-chip Fourier Transform Spectrometers.

Journal of low temperature physics·2022
Same author

Durable memories and efficient neural coding through mnemonic training using the method of loci.

Science advances·2021
Same author

The renin secretion profile under the influence of sleep deprivation and the neuropeptides CRH and GHRH.

Psychoneuroendocrinology·2020
Same author

Salivary cortisol response to psychosocial stress in the late evening depends on CRHR1 genotype.

Psychoneuroendocrinology·2020
Same author

Background corrected measurements of optical quantities in the far-infrared spectral range.

Optics express·2019

Area of Science:

  • Neuroendocrinology
  • Sleep Medicine
  • Gerontology

Context:

  • Sleep disturbances are common in depression and aging.
  • Nocturnal hormone secretion and sleep EEG show decreased slow-wave sleep and disturbed continuity in these conditions compared to younger controls.

Purpose:

  • To investigate the role of neuropeptides in sleep-endocrine regulation during aging and depression.
  • To explore the common regulators of peripheral hormone secretion and sleep structure.

Summary:

  • Simultaneous sleep EEG and nocturnal hormone secretion studies reveal reduced slow-wave sleep and disturbed sleep continuity in aging and depression.
  • Animal studies and human data indicate that growth hormone-releasing hormone (GHRH) and corticotropin-releasing hormone (CRH) are key regulators of both hormone secretion and sleep architecture.

Related Experiment Videos

  • Changes in the GHRH/CRH ratio are hypothesized to be central to the pathophysiology of sleep-endocrine abnormalities in aging and depression.

    • Impact:

    • Provides insights into the neuroendocrine mechanisms underlying sleep disturbances in aging and depression.
    • Suggests potential therapeutic targets for sleep and hormonal dysregulation in these populations.
    • Highlights the interconnectedness of sleep, aging, depression, and hormonal balance.