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Blood pressure and atrial natriuretic peptides correlate throughout the day

R B Sothern1, D L Vesely, E L Kanabrocki

  • 1Rhythmometry Laboratory, St. Paul-Ramsey Medical Center, Minneapolis, Minn., USA.

American Heart Journal
|May 1, 1995
PubMed

Insights

Atrial natriuretic peptides, including vessel dilator and atrial natriuretic factor (ANF), show inverse correlations with blood pressure. These findings suggest their crucial role in maintaining normal blood pressure levels in humans.

Area of Science:

  • Cardiovascular Physiology
  • Endocrinology
  • Human Physiology

Background:

  • Atrial natriuretic peptides, such as vessel dilator and atrial natriuretic factor (ANF), are known for their vasodilatory effects.
  • Circulating levels of these peptides and their relationship with blood pressure regulation in normotensive individuals require further investigation.

Purpose of the Study:

  • To investigate the relationship between circulating atrial natriuretic peptides (vessel dilator and ANF) and blood pressure in healthy humans.
  • To examine the circadian rhythms of these peptides and their correlation with naturally occurring blood pressure variations over time.

Main Methods:

  • Longitudinal study examining seven healthy individuals in 1988 and 1993.
  • Measurement of circulating vessel dilator and ANF concentrations.
  • Monitoring of circadian rhythms of mean arterial pressure, systolic blood pressure, and diastolic blood pressure.

Main Results:

  • Both vessel dilator and ANF exhibited significant circadian rhythms, with peak concentrations around 4:00 AM.
  • Blood pressure parameters (mean arterial, systolic, diastolic) showed circadian rhythms opposite to those of the peptides.
  • A significant inverse correlation was observed between 24-hour averages of blood pressure and circulating levels of vessel dilator and ANF.

Conclusions:

  • Circulating vessel dilator and ANF demonstrate significant circadian variations.
  • These peptides are inversely correlated with blood pressure in normotensive individuals.
  • Atrial natriuretic peptides play a vital role in maintaining blood pressure within the normotensive range.

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