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Direct electron transfer bioelectronic interfaces: application to clinical analysis

C J McNeil1, D Athey, W O Ho

  • 1Department of Clinical Biochemistry, Medical School, University of Newcastle upon Tyne, UK.

Biosensors & Bioelectronics
|January 1, 1995
PubMed
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This study presents bioelectronic interfaces for detecting free radicals like superoxide anion radical (O2(-). These systems utilize immobilized enzymes for potential in vivo monitoring of inflammation-related diseases.

Area of Science:

  • Bioelectrochemistry
  • Biosensors
  • Enzyme Electrodes

Background:

  • Direct electron transfer (DET) bioelectronic interfaces are under development for clinical measurements.
  • Free radicals, such as superoxide anion radical (O2(-), are implicated in inflammatory diseases.

Purpose of the Study:

  • To outline the potential of two bioelectronic systems for clinical measurement.
  • To develop a reagentless system for continuous in vivo monitoring of free radical activity.

Main Methods:

  • Covalent immobilization of cytochrome c onto N-acetyl cysteine-modified gold electrodes for O2(-) detection.
  • Construction of horseradish peroxidase enzyme electrodes (HRP-ACE) on activated carbon via passive adsorption.

Main Results:

Related Experiment Videos

  • Demonstrated direct electrochemistry of immobilized cytochrome c for O2(-) detection with an electron transfer rate constant (ket) of 3.4 ± 1.2 s(-1).
  • Established a direct proportionality between current generation and O2(-) production rate.
  • Developed a reagentless system for O2(-) monitoring.

Conclusions:

  • The developed bioelectronic interfaces show promise for clinical diagnostics and continuous in vivo monitoring.
  • These systems offer a potential tool for understanding and managing inflammatory and neurodegenerative disorders.