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[Nonspecific bronchial provocation with histamine and methacholine]
1Clinica Medicală 3, Târgu Mures.
Pneumoftiziologia : Revista Societatii Romane De Pneumoftiziologie
|January 1, 1994
Summary
The histamine and methacholine inhalation test estimates bronchial reactivity using continuously generated aerosols. This method helps diagnose asthma and aids in drug research by measuring airway response.
Area of Science:
- Pulmonology
- Pharmacology
Context:
- Bronchial reactivity testing is crucial for diagnosing respiratory conditions.
- Continuously generated aerosol inhalation has emerged as a recognized method over the past decade.
Purpose:
- To outline the standardized procedure for bronchial reactivity testing using histamine and methacholine.
- To describe the methodology involving serial drug inhalations and measurement of Maximal Expiratory Vital Spirometry (MEVS).
- To establish the concentration or dose required to decrease MEVS by 20% (PC20 or PD20) as an index of bronchial reactivity.
Summary:
- The test involves 2-minute inhalations of doubling drug doses every 5 minutes, followed by MEVS measurement to create a dose-response curve.
- PC20 or PD20 values, indicating the drug concentration/dose for a 20% MEVS decrease, serve as key indices for bronchial hyperresponsiveness.
- This method is applicable for suspected atypical asthma, occupational asthma, and pharmaceutical research.
Impact:
- Ensures accurate assessment of airway hyperresponsiveness.
- Provides a standardized approach for diagnosing and managing asthma.
- Facilitates objective evaluation in drug development and clinical trials for respiratory medications.