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Related Experiment Videos

Binge eating disorder: response to naltrexone

M A Marrazzi1, K M Markham, J Kinzie

  • 1Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan 48901, USA.

International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity
|February 1, 1995
PubMed
Summary

Naltrexone, an opiate antagonist, reduced binge eating disorder (BED) symptoms in a single-subject study. Combined with psychotherapy, naltrexone may offer a more effective treatment for BED than psychotherapy alone.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Clinical Psychology

Background:

  • Binge eating disorder (BED) involves recurrent binge eating without compensatory behaviors, often linked to obesity.
  • Previous research demonstrated naltrexone's efficacy in treating bulimia nervosa.
  • This study investigates naltrexone's potential in treating BED, drawing parallels to bulimia nervosa treatment responses.

Observation:

  • A single-subject, 'n of one' study design was employed, utilizing three consecutive periods: drug, placebo, and double-dose drug.
  • The double-blind, placebo-controlled methodology ensured rigorous data collection.
  • Psychotherapy was administered consistently throughout all study periods.

Findings:

  • Naltrexone administration resulted in a significant reduction of BED symptoms compared to the placebo period.

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  • Time series analysis confirmed the statistical significance of the observed symptom reduction.
  • The individual's response to naltrexone mirrored findings from larger trials on bulimia nervosa.

    • Implications:

    • Naltrexone, in conjunction with psychotherapy, shows promise as a more effective treatment for BED than psychotherapy alone.
    • This case study supports further investigation into opiate antagonists for BED treatment.
    • Findings contribute to understanding the neurobiological underpinnings of BED and potential therapeutic targets.