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Related Experiment Videos

High-dose naltrexone and liver function safety

M A Marrazzi1, J M Wroblewski, J Kinzie

  • 1Department of Psychiatry, Harper-Grace Hospitals, Detroit, MI, USA.

The American Journal on Addictions
|January 1, 1997
PubMed
Summary
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High-dose naltrexone (Naltrexone) is safe for treating eating disorders. This study found no adverse liver function changes in patients receiving high-dose naltrexone therapy.

Area of Science:

  • Pharmacology
  • Gastroenterology
  • Psychiatry

Background:

  • Naltrexone is used for conditions beyond opiate addiction, like alcoholism and eating disorders, where endogenous opioids are implicated.
  • Some studies utilize high naltrexone doses (100-200 mg twice daily).
  • Prior research indicated potential liver enzyme elevations with very high doses (300 mg/day).

Purpose of the Study:

  • To assess the safety of high-dose naltrexone on liver function in patients with eating disorders.
  • To evaluate liver function parameters during a double-blind, crossover trial and an open-label period of naltrexone therapy.

Main Methods:

  • A double-blind, crossover trial using naltrexone at 100 mg twice daily.
  • Followed by an open-label period with naltrexone at 200 mg twice daily.

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  • Monitoring of various liver function parameters throughout the study.

    • Main Results:

    • No clinically significant adverse changes in liver function were observed.
    • Laboratory liver function tests remained within normal limits.
    • Patients tolerated high-dose naltrexone therapy well.

    Conclusions:

    • High-dose naltrexone therapy (up to 200 mg twice daily) appears safe for individuals with eating disorders.
    • Naltrexone does not adversely affect liver function in this patient population at the studied doses.
    • Further research can explore naltrexone's efficacy in treating eating disorders with monitored liver function.