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Related Experiment Videos

Circulating ICAM-1 is increased in septic shock

C N Sessler1, A C Windsor, M Schwartz

  • 1Department of Internal Medicine, Medical College of Virginia-Virginia Commonwealth University, Richmond, USA.

American Journal of Respiratory and Critical Care Medicine
|May 1, 1995
PubMed
Summary

Circulating intercellular adhesion molecule-1 (cICAM-1) is elevated in sepsis patients and correlates with shock severity. This marker may indicate endothelial activation in critical illness, impacting patient outcomes.

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Area of Science:

  • Immunology
  • Critical Care Medicine
  • Biomarker Research

Background:

  • Adhesion molecules mediate neutrophil-endothelial interactions during inflammation.
  • Soluble intercellular adhesion molecule-1 (cICAM-1) is elevated in inflammatory states.

Purpose of the Study:

  • Measure cICAM-1 levels in septic adults.
  • Assess the relationship between cICAM-1 and sepsis outcomes like organ failure and death.

Main Methods:

  • Sandwich-type enzyme-linked immunosorbent assay (ELISA) used for cICAM-1 measurement.
  • Blood samples collected within 12 hours of ICU admission.
  • Comparison between septic patients, healthy volunteers, and non-septic ICU patients.

Main Results:

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  • Septic patients showed significantly higher cICAM-1 levels than healthy volunteers (1,259 vs. 355 ng/ml).
  • Elevated cICAM-1 was also observed in patients with Systemic Inflammatory Response Syndrome (SIRS) without infection.
  • Day 1 cICAM-1 levels positively correlated with septic shock severity (hypotension, vasopressor use).

Conclusions:

  • cICAM-1 is a potential marker of endothelial activation in sepsis.
  • Elevated cICAM-1 levels are associated with increased sepsis severity and shock.
  • Further research may explore cICAM-1's role in predicting sepsis complications.