Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Physiologic changes during growth and development

E J O'Flaherty1

  • 1Department of Environmental Health, College of Medicine, University of Cincinnati, Ohio 45267, USA.

Environmental Health Perspectives
|December 1, 1994
PubMed
Summary

Physiologic functions often follow allometric scaling laws (y = axb), but some processes depend on age-related physicochemical changes, impacting kinetic modeling. Understanding these relationships is crucial for accurate biological modeling.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of Particle Clearance and Retention Kinetics in the Lungs of U.S. Coal Miners.

Inhalation toxicology·2015
Same author

A biomathematical model of particle clearance and retention in the lungs of coal miners.

Regulatory toxicology and pharmacology : RTP·2001
Same author

A physiologically based model for the ingestion of chromium(III) and chromium(VI) by humans.

Toxicological sciences : an official journal of the Society of Toxicology·2001
Same author

Modeling normal aging bone loss, with consideration of bone loss in osteoporosis.

Toxicological sciences : an official journal of the Society of Toxicology·2000
Same author

Lessons learned in applying the U.S. EPA proposed cancer guidelines to specific compounds.

Toxicological sciences : an official journal of the Society of Toxicology·2000
Same author

The O'Flaherty model of lead kinetics: an evaluation using data from a lead smelter population.

Toxicology and applied pharmacology·1999

Area of Science:

  • Physiology
  • Pharmacokinetics
  • Biomathematics

Background:

  • Physiologic and anatomic functions often exhibit allometric scaling (y = axb) across species.
  • This scaling applies to organ weights, glomerular filtration rate, respiration, oxygen consumption, and basal metabolic rate.
  • Allometric relationships can show slope discontinuities during critical growth phases.

Purpose of the Study:

  • To identify simple mathematical expressions for growth-related changes in physiologic functions for kinetic modeling.
  • To examine different types of age-dependence in kinetically important processes.
  • To analyze the combined impact of these factors on age-dependent lead kinetics.

Main Methods:

  • Utilizing the allometric relationship (y = axb) to model physiologic functions.
  • Analyzing age-dependence of physicochemical characteristics and their interactions.
  • Examining the age-dependence of lead-kinetic behavior.

Main Results:

  • Demonstrated that many physiologic functions follow allometric scaling.
  • Identified that other processes are governed by age-dependent physicochemical interactions.
  • Showcased the combined influence on age-dependent lead kinetics.

Conclusions:

  • Allometric scaling is a key model for many growth-related physiologic changes.
  • Age-dependent physicochemical properties significantly influence other kinetic processes.
  • A comprehensive approach is needed to model age-dependent kinetic behaviors, exemplified by lead kinetics.

Related Experiment Videos