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T Cell Activation and Clonal Selection

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Related Experiment Video

Updated: May 5, 2026

Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals

Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals

Published on: January 5, 2016

CD8 naive T cell counts decrease progressively in HIV-infected adults

M Roederer¹, J G Dubs, M T Anderson

¹Department of Genetics, Stanford University School of Medicine, California 94305, USA.

The Journal of Clinical Investigation

|May 1, 1995

Summary

This summary is machine-generated.

Human immunodeficiency virus (HIV) infection depletes crucial naive CD4 and CD8 T cells during the asymptomatic stage. This loss of naive T cells, vital for immune responses, contributes to HIV-related immunodeficiency.

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Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Published on: December 3, 2019

Area of Science:

Immunology
Virology
Infectious Diseases

Background:

Human immunodeficiency virus (HIV) infection is characterized by a progressive decline in CD4 T cells.
The role of CD8 T cells, particularly naive subsets, during early HIV infection remains incompletely understood.
Understanding T cell dynamics is crucial for deciphering HIV pathogenesis and immune dysfunction.

Purpose of the Study:

To investigate the changes in naive and memory CD4 and CD8 T cell populations during the asymptomatic stage of HIV infection.
To elucidate the contribution of naive T cell depletion to HIV-induced immunodeficiency.

Main Methods:

Flow cytometry analysis of peripheral blood mononuclear cells (PBMCs) to quantify CD4 and CD8 T cell subsets (naive and memory).
Correlation analysis between T cell subset counts and CD4 T cell levels in HIV-infected adults and children.

Main Results:

CD8 naive T cells are progressively depleted during the asymptomatic stage of HIV infection, paralleling CD4 T cell decline.
Naive CD4 T cells are preferentially lost as total CD4 counts decrease.
Increased total CD8 T cell counts in HIV infection are primarily due to an expansion of memory CD8 T cells, not naive cells.

Conclusions:

HIV disease involves the significant loss of both naive CD4 and CD8 T cells, a finding demonstrated in both adults and children.
Naive T cell depletion offers new insights into the mechanisms of immunodeficiency in HIV-infected individuals.
The shift towards memory T cells has critical implications for interpreting functional immunological studies in HIV.