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Transverse vaginal septum. A case report

J Wang¹, W Ezzat, M Davidson

¹Department of Obstetrics and Gynecology, Royal University Hospital, Saskatoon, Saskatchewan, Canada.

The Journal of Reproductive Medicine

|February 1, 1995

Summary

A rare case of a complete transverse vaginal septum, a congenital abnormality, caused primary amenorrhea in a 16-year-old. This condition, associated with syndactyly, has not been previously reported in medical literature.

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Area of Science:

Reproductive medicine
Gynecology
Medical genetics

Background:

Transverse vaginal septum is a rare congenital anomaly that can lead to primary amenorrhea and hematocolpos.
Diagnosis can be challenging due to its low position, sometimes mimicking an imperforate hymen.
Müllerian duct abnormalities are a spectrum of congenital conditions affecting the female reproductive tract.

Observation:

A 16-year-old patient presented with primary amenorrhea and was diagnosed with a hematocolpos.
A complete transverse vaginal septum was identified in the lower third of the vagina.
The patient also exhibited syndactyly of the second and third toes on her right foot.

Findings:

Histological examination confirmed the diagnosis of transverse vaginal septum, identifying mesodermal (Müllerian duct) origin tissue.
Surgical excision of the septum was performed.
The co-occurrence of a transverse vaginal septum and syndactyly in this patient is a novel observation.

Implications:

This case highlights the importance of thorough gynecological evaluation in cases of primary amenorrhea.
The association suggests a potential, previously unreported, link between Müllerian duct anomalies and limb malformations.
Further research may elucidate shared developmental pathways or genetic factors underlying these combined congenital abnormalities.

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