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Updated: Aug 18, 2026

Microsurgical Venous Pouch Arterial-Bifurcation Aneurysms in the Rabbit Model: Technical Aspects
Published on: May 11, 2011
Prevention of venous thrombosis in microvascular surgery by transmural release of heparin from a polyanhydride
L A Orloff1, M G Glenn, A J Domb
1Division of Otolaryngology-Head and Neck Surgery, University of California, San Diego Medical Center 92103-8891, USA.
Background:
The effects of transmurally released heparin on the patency of microvenous anastomoses were studied by using a bioerodible polymer delivery system in a rat microvascular thrombosis model.
Methods:
A polyanhydride carrier with heparin was wrapped around the outside of a highly thrombogenic venous inversion graft in 14 animals, and patency rates were compared with those of 17 control animals.
Results:
Anastomotic patency was significantly greater in the groups treated with transmurally released heparin, measured both at 24 hours (86% versus 16%; p < 0.02) and at 7 days (86% versus 36%; p < 0.05) after operation. No significant complications occurred.
Conclusions:
Controlled release of heparin by transmural delivery is an effective and safe form of local antithrombotic therapy and may have applications both in microvascular and large vessel surgery.
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