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Related Experiment Videos

New method for measuring ICG Rmax with a clearance meter

S Shimizu1, W Kamiike, N Hatanaka

  • 1First Department of Surgery, Osaka University Medical School, Suita, Japan.

World Journal of Surgery
|January 1, 1995
PubMed
Summary
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A new method using the RK-1000 clearance meter accurately measures indocyanine green maximal removal rate (ICG Rmax), a key indicator of liver function. This improved technique offers a more reliable assessment of hepatic function compared to older methods.

Area of Science:

  • Hepatology
  • Biomedical Engineering
  • Clinical Diagnostics

Background:

  • The maximal removal rate of indocyanine green (ICG Rmax) is a critical parameter for assessing hepatic function.
  • Existing methods for ICG Rmax analysis have limitations, leading to inaccurate results in approximately 15% of patients.

Purpose of the Study:

  • To develop and validate a novel method for measuring ICG Rmax using a continuous clearance meter (RK-1000).
  • To enhance the accuracy and reliability of hepatic function assessment through improved ICG Rmax measurement.

Main Methods:

  • Developed a new method utilizing the RK-1000 clearance meter with a fingertip optical sensor for continuous in vivo ICG concentration measurement.
  • Applied the Michaelis-Menten model, subtracting VLDL compartment ICG concentration due to protein binding, to calculate Rmax.

Related Experiment Videos

  • Utilized Lineweaver-Burk plot analysis to determine Rmax from calculated removal velocity.

    • Main Results:

    • The study included 20 patients: 10 normal, 6 with cirrhosis, and 4 with hepatitis.
    • Continuous ICG concentration was measured in vivo using the RK-1000.
    • Significantly lower Rmax values were observed in patients with liver disease compared to healthy individuals.

    Conclusions:

    • The novel RK-1000 method provides an appropriate reflection of liver function.
    • This new approach offers a more accurate and reliable assessment of hepatic function by overcoming the limitations of previous ICG Rmax measurement techniques.