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Gastritis in Barrett's esophagus
1Department of Surgery, University of the Witwatersrand Medical School, Parktown, Johannesburg, South Africa.
World Journal of Surgery
|January 1, 1995
Summary
Duodenogastric reflux is linked to gastric ulceration in Barrett's esophagus patients. Reactive chronic gastritis, identified via histology, suggests significant pathophysiologic and therapeutic implications for this condition.
Area of Science:
- Gastroenterology
- Pathophysiology
- Histopathology
Background:
- Duodenogastric reflux is a suspected factor in complicated Barrett's esophagus and gastric ulceration.
- Barrett's esophagus affects the esophagus lining, increasing cancer risk.
- Gastric ulceration (GU) is a serious complication.
Purpose of the Study:
- To investigate the association between duodenogastric reflux and gastric histology in Barrett's esophagus patients.
- To determine the prevalence of reactive chronic gastritis in this patient group.
- To explore the clinical implications of these findings.
Main Methods:
- Prospective follow-up of 123 Barrett's esophagus patients for a mean of 41 months.
- Review of gastric histology using the Sydney system for 54 patients.
- Assessment of duodenogastric reflux using the bile reflux index.
Main Results:
- Nine (7%) patients developed gastric ulceration (GU).
- Among patients treated with antireflux surgery, 14% developed GU.
- Reactive chronic gastritis was present in 74% of patients, with 45% showing histologic evidence of duodenogastric reflux.
Conclusions:
- Reactive chronic gastritis is common in Barrett's esophagus patients.
- Histologic evidence of duodenogastric reflux is frequently observed in these patients.
- The presence of reactive chronic gastritis has potential pathophysiologic and therapeutic significance.