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Inhibitory activity of anti-beta 2-glycoprotein I antibody on factor Va degradation by activated-protein C and its
J Matsuda1, K Gohchi, K Kawasugi
1Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan.
American Journal of Hematology
|May 1, 1995
Abstract:
We investigated the influence of anti-beta 2-glycoprotein I (aGPI), which recently has come to be regarded as anti-cardiolipin antibody (aCL) itself, on factor Va (FVa) degradation by activated protein C/protein S system. We found that aGPI had an inhibitory effect on FVa degradation with beta 2-glycoprotein I-dependency, thus suggesting aGPI/aCL is a highly possible factor as the pathogenesis of thrombosis observed in aGPI/aCL-positive patients.