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Thyroid function and pubertal development in malnutrition

O Ali1, T T Tan, O Sakinah

  • 1Department of Community Health, Medical Faculty, Universiti Kebangsaan Malaysia, Kuala Lumpur.

Annals of the Academy of Medicine, Singapore
|November 1, 1994
PubMed
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Thyroid hormone levels (T3, T4, TSH) and growth hormone varied significantly between ethnic groups (Malays, Orang Asli) and socioeconomic statuses in Malaysian children and adults. Nutritional status and goitre impacted thyroid function.

Area of Science:

  • Endocrinology
  • Public Health
  • Human Biology

Background:

  • Thyroid function and pubertal development are crucial for overall health.
  • Socioeconomic factors can influence physiological parameters.
  • Ethnic variations in health markers are common in diverse populations.

Purpose of the Study:

  • To assess thyroid function and pubertal development in Orang Asli and Malay populations across different socioeconomic strata.
  • To investigate the relationship between socioeconomic status, ethnicity, and endocrine markers.
  • To identify factors influencing thyroid hormone and growth hormone levels.

Main Methods:

  • A cross-sectional study involving 1136 subjects aged 7 years and above.
  • Measurements included anthropometry, goitre assessment, pubertal staging, and serum levels of thyroxine (T4), triiodothyronine (T3), thyroid stimulating hormone (TSH), and growth hormone (GH).

Related Experiment Videos

  • Radioimmunoassays (RIA) and immunoradiometric assays (IRMA) were utilized for hormone quantification.

    • Main Results:

    • Serum T3 was higher in rural Malays, girls, and younger children; associated with anthropometrics in adults.
    • Serum T4 was higher in urban children, linked to nutritional status and social development in adults.
    • Serum TSH was higher in Orang Asli and malnourished children.
    • Growth hormone was higher in less privileged groups and negatively correlated with anthropometrics and malnutrition.
    • Nutritional status predicted T3; goitre predicted T4 and TSH (in children).

    Conclusions:

    • Socioeconomic status, ethnicity, and nutritional status significantly influence thyroid hormone levels and growth hormone secretion.
    • Goitre is an important determinant of thyroid hormone levels.
    • Findings highlight the interplay of environmental and biological factors on endocrine health in diverse Malaysian populations.