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[A comparative study in rectal adenocarcinoma: preoperative or postoperative radiotherapy]
C Martín de Vidales1, L Cerezo, M L Vázquez de la Torre
1Servicio de Radioterapia y Oncología, Hospital de la Princesa, Madrid.
Purpose:
To compare the results of preoperative and postoperative radiotherapy in rectal adenocarcinoma, in terms of overall survival and disease-free survival.
Patients And Methods:
From 1989 to 1993, 52 patients with clinically operable rectal cancer were retrospectively analyzed. Two groups were compared: Patients in Group I received postoperative radiotherapy and those in Group II preoperative radiotherapy. Patients with a Karfnosky index > 70%, no evidence of distant disease and no major systemic problems were included in this study.
Results:
The overall 5-year actuarial survival was 75% in Group I and 83% in Group II. The 5-year disease-free survival was 52% in Group I compared to 86% in Group II, a statistically significant difference (p = 0.025). A reduction in all Dukes' stages was observed in the preoperative radiation group, allowing preservation of the anorectal function in an increased number of patients.
Conclusions:
We observed better results with preoperative radiotherapy and conclude that this treatment might be justified in rectal carcinoma.
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