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Related Experiment Videos

Transdermal non-steroidal anti-inflammatory agents

R Grahame1

  • 1Rheumatology Department, Guy's Hospital, London.

The British Journal of Clinical Practice
|January 1, 1995
PubMed
Summary

Topical non-steroidal anti-inflammatory drugs (T/NSAIDs) offer an alternative for musculoskeletal pain relief, bypassing gastrointestinal risks associated with oral NSAIDs. They aim for high local drug concentration with minimal systemic absorption.

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Area of Science:

  • Pharmacology
  • Drug Delivery Systems
  • Rheumatology

Background:

  • Oral non-steroidal anti-inflammatory drugs (NSAIDs) are associated with significant gastrointestinal morbidity, especially in the elderly.
  • Musculoskeletal and joint pain management necessitates safer alternatives to oral NSAIDs.
  • Transdermal drug delivery has proven successful for various medications, suggesting potential for NSAIDs.

Purpose of the Study:

  • To review pharmacokinetic data of topical non-steroidal anti-inflammatory drugs (T/NSAIDs).
  • To evaluate the efficacy and safety evidence for T/NSAIDs.
  • To assess the current role of T/NSAIDs in medical practice.

Main Methods:

  • Review of pharmacokinetic data for T/NSAIDs.
  • Analysis of clinical trial data on T/NSAID efficacy and safety.
  • Assessment of T/NSAID formulations and their therapeutic goals.

Main Results:

  • T/NSAIDs aim for high local drug concentration at the application site.
  • The goal is to achieve minimal plasma concentration to reduce systemic and gastrointestinal adverse effects.
  • Several T/NSAIDs are licensed, with others under investigation.

Conclusions:

  • T/NSAIDs represent a viable alternative for managing musculoskeletal and joint pain.
  • They offer a favorable safety profile by minimizing systemic exposure compared to oral NSAIDs.
  • Further assessment of T/NSAIDs' place in current medical practice is warranted.

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