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09:15
Electrochemiluminescence Assays for Human Islet Autoantibodies
Published on: March 23, 2018
[Humoral autoimmunity markers in autoimmune endocrine diseases]
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk
|January 1, 1994
Summary
Autoantibodies to fibroblasts may predict vascular complications in insulin-dependent diabetes mellitus (IDDM). Autoantibodies to thyroid microsomal antigen (ATMA) are linked to thyroid dysfunction in IDDM patients.
Area of Science:
- Endocrinology
- Immunology
- Autoimmunity
Context:
- Autoimmune diseases often involve multiple endocrine glands.
- Understanding autoantibody profiles can elucidate disease pathogenesis and predict complications.
Purpose:
- To investigate the role of various autoantibodies as risk factors for complications in endocrine disorders.
- To assess the incidence and significance of autoantibodies in patients with Type 1 diabetes (IDDM), Type 2 diabetes (NIDDM), and thyroid diseases.
Summary:
- The study examined autoantibodies against thyroid microsomal antigen (ATMA), thyroglobulin, islet cells, adrenal cortex, adenohypophyseal cells, and skin fibroblasts in various endocrine conditions.
- Polyclonal immune activation was common, with higher rates of multiple autoantibodies in Graves' disease than in IDDM.
- Persistence of fibroblast antibodies in IDDM patients correlated with vascular complications, suggesting predictive value.
- Thyroidal dysfunction developed in all IDDM patients with persistent ATMA, highlighting its association with thyroid issues.
Impact:
- Fibroblast antibodies may serve as predictive markers for late diabetic complications, particularly vascular issues.
- ATMA presence is a significant indicator for the development of thyroidal dysfunction in IDDM patients.
- Findings contribute to understanding the complex interplay of autoimmunity in endocrine diseases and their complications.
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