Lung perfusion and other methods of targeting therapy to lung tumors

As therapies for cancer and other diseases continue to evolve on a molecular and genetic basis, delivering these sophisticated agents will continue to be problematic. Although the agents may be highly effective in the laboratory, their true worth can only be measured by clinical responses. In certain instances, the skills of a thoracic surgeon may be called upon to provide the means of delivering therapy rather than to perform therapy, as is our custom. The techniques discussed in this review are just a few of the many possibilities for targeting agents in an effort to enhance their clinical efficacy.