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Plasma norepinephrine and mortality

J N Cohn1

  • 1Department of Medicine, University of Minnesota Medical School, Minneapolis 55455, USA.

Clinical Cardiology
|March 1, 1995
PubMed
Summary
This summary is machine-generated.

Elevated plasma norepinephrine levels indicate increased sympathetic nervous system activity in heart failure (HF). Higher levels correlate with poor prognosis, suggesting a need for interventions targeting neurohormonal activation in HF patients.

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Area of Science:

  • Cardiology
  • Neuroendocrinology

Background:

  • Plasma norepinephrine levels reflect sympathetic nervous system (SNS) activity.
  • Elevated SNS activity is common in patients with left ventricular dysfunction and heart failure (HF).

Purpose of the Study:

  • To investigate the prognostic significance of plasma norepinephrine levels in patients with left ventricular dysfunction.
  • To explore the relationship between plasma norepinephrine levels and clinical variables in HF.

Main Methods:

  • Review of existing data on plasma norepinephrine levels in patients with left ventricular dysfunction.
  • Analysis of data from the V-HeFT II trial.

Main Results:

  • Plasma norepinephrine levels are almost universally elevated in left ventricular dysfunction, correlating with prognosis.

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  • Patients with levels > 900 pg/ml have a poor prognosis.
  • Progressive increases in norepinephrine were observed despite ACE inhibitor or vasodilator therapy, indicating disease progression.

    • Conclusions:

    • Elevated plasma norepinephrine is a significant prognostic marker in heart failure.
    • Current therapies may not fully address the underlying neurohormonal activation.
    • Interventions targeting neurohormonal activation may improve HF outcomes.