[Investigation of drug release in vitro from mitoxantrone-nanospheres]

We observed the rules of drug release in vitro from a liver targeting preparation-mitoxantrone polybutylcyanoacrylate nanospheres freeze-drying injection by dynamic penetration system and spectrophotometry. The results showed that the drug release of this nanospheres preparation accorded with the two phases kinetics rules in vitro. In the process of drug release, there were two phases. The first phase was a quick release phase, the quantity of released drug within 4 hours being more than 40%, t1/2 alpha = 1.40h. The second phase was a slow release phase, t1/2 beta = 169.02h. The rules of drug release accord with the normal rules of drug use. The preparation may be clinically used.