[Primary culture of different renal cell carcinoma cells with respect to immunomodulatory effects]

The presented results show that renal cell carcinomas (RCC) have partial immunomodulatory capacity (production of cytokines as IL-6, -10, -11; modulation of mitogen-induced transformation of T lymphocytes). The production of IL-10 shows a tendency to correlate with higher staging and grading of RCC. The cytokine production does not correlate with specific types of RCC. Direct immunosuppression of T lymphocytes in lymphocyte transformation tests (LTT) was not detectable.