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Human parvovirus B19 can infect cynomolgus monkey marrow cells in tissue culture
G Gallinella1, S M Anderson, N S Young
1Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.
Journal of Virology
|June 1, 1995
Abstract:
The human pathogenic parvovirus B19 cannot be grown in standard tissue culture but propagates in human bone marrow, where it is cytotoxic to erythroid progenitor cells. We now show that parvovirus B19 can replicate in cynomolgus bone marrow. Cynomolgus monkeys may be a suitable animal model for pathogenesis studies of parvovirus B19.
Insights
Parvovirus B19, a human pathogen, replicates in cynomolgus monkey bone marrow. This finding suggests cynomolgus monkeys are a potential animal model for studying parvovirus B19 pathogenesis.
Area of Science:
- Virology
- Primate Models
Background:
- Human parvovirus B19 is a significant human pathogen.
- It is cytotoxic to erythroid progenitor cells in human bone marrow.
- Standard tissue culture methods are insufficient for parvovirus B19 propagation.
Purpose of the Study:
- To investigate the potential of cynomolgus bone marrow for parvovirus B19 replication.
- To evaluate cynomolgus monkeys as an animal model for parvovirus B19 pathogenesis.
Main Methods:
- Culturing parvovirus B19 in cynomolgus bone marrow.
- Observing viral replication within the primate bone marrow environment.
Main Results:
- Parvovirus B19 successfully replicated in cynomolgus bone marrow.
- Demonstrated viral propagation in a non-human primate bone marrow model.
Conclusions:
- Cynomolgus bone marrow supports parvovirus B19 replication.
- Cynomolgus monkeys represent a promising animal model for parvovirus B19 research.