Related Experiment Videos
Apoptosis as a cause of death in measles virus-infected cells
L M Esolen1, S W Park, J M Hardwick
1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Journal of Virology
|June 1, 1995
Abstract:
To determine the mechanism of measles virus-induced cell death, we studied the infection of Vero cells and monocytic cell lines with wild-type (Chicago-1) and vaccine (Edmonston) strains of measles virus. DNA fragmentation indicative of apoptosis was apparent by flow cytometry, agarose gel electrophoresis, and electron microscopy. Within syncytia, DNA strand breaks were demonstrated by end labeling with terminal transferase and then by visualization.