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Glycoprotein B of bovine herpesvirus-1 binds heparin
K M Byrne1, D W Horohov, K G Kousoulas
1Department of Veterinary Microbiology and Parasitology, School of Veterinary Medicine, Louisiana State University, Baton Rouge 70803, USA.
Virology
|May 10, 1995
Abstract:
Many members of the herpesvirus family have been shown to bind heparan sulfate on the surface of target cells. A previous report on bovine herpesvirus-1 (BHV-1) glycoprotein interactions indicated that only gC bound to heparin-agarose columns. In this report, we demonstrated that both gC and gB of wild-type BHV-1 bound to heparin-agarose columns and that gC-minus virus infectivity was inhibited by heparin.