Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transcript identification in the BRCA1 candidate region

B L Weber1, K J Abel, F J Couch

  • 1Department of Internal Medicine, University of Michigan, Ann Arbor, USA.

Breast Cancer Research and Treatment
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association between type and location of germline BRCA1/2 pathogenic or likely pathogenic variants with phenotype and prognosis in young patients with breast cancer: results from an international cohort study.

Annals of oncology : official journal of the European Society for Medical Oncology·2025
Same author

Association of gene variant type and location with breast cancer risk in the general population.

Annals of oncology : official journal of the European Society for Medical Oncology·2025
Same author

Genome Wide Conditional Mouse Knockout Resources.

Drug discovery today. Disease models·2024
Same author

Impact of hormone receptor status and tumor subtypes of breast cancer in young BRCA carriers.

Annals of oncology : official journal of the European Society for Medical Oncology·2024
Same author

BRCA1 and BRCA2 genetic testing-pitfalls and recommendations for managing variants of uncertain clinical significance.

Annals of oncology : official journal of the European Society for Medical Oncology·2015
Same author

Genetic counselors' practices and confidence regarding variant of uncertain significance results and reclassification from BRCA testing.

Clinical genetics·2015
Same journal

Comments on: Cost-effectiveness of DPYD genotyping prior to capecitabine administration for metastatic breast cancer.

Breast cancer research and treatment·2026
Same journal

Comments on: Predictors of pathologic complete response in early-stage triple-negative breast cancer treated with neoadjuvant chemo-immunotherapy.

Breast cancer research and treatment·2026
Same journal

Discrimination, spectrum, and clinical utility: ICG lymphography drainage time in axillary staging.

Breast cancer research and treatment·2026
Same journal

Tumor infiltrating lymphocytes (TILs) as a predictive marker of pathological complete response (pCR) in a diverse patient population with early triple negative breast cancer (TNBC) treated with neoadjuvant real-world KEYNOTE-522 regimen.

Breast cancer research and treatment·2026
Same journal

Role of individualized intervention(s) on quality of life and adherence to adjuvant endocrine therapy in premenopausal women with early-stage breast cancer: MyCHOICE study.

Breast cancer research and treatment·2026
Same journal

Subjective socioeconomic status moderates the relationship between objective neighborhood disadvantage and quality of life in middle- and older-aged women with breast cancer.

Breast cancer research and treatment·2026
See all related articles

Researchers are identifying genes on chromosome 17q12-21 linked to early-onset breast and ovarian cancer (BRCA1). This work aims to understand cancer development and create screening methods for at-risk women.

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • Chromosome 17q12-21 is implicated in hereditary breast and ovarian cancer.
  • Identifying the BRCA1 gene is crucial for understanding cancer pathogenesis and developing diagnostics.

Purpose of the Study:

  • To identify candidate genes within the BRCA1 region.
  • To characterize identified transcripts for potential BRCA1 mutations.

Main Methods:

  • Utilized cDNA screening, exon amplification, and magnetic bead capture to identify transcripts.
  • Characterized transcripts by tissue expression, genomic rearrangement, and homology searches.
  • Analyzed DNA from families with hereditary breast and ovarian cancer linkage.

Main Results:

Related Experiment Videos

  • Several transcripts were identified from the BRCA1 candidate region.
  • Characterization is ongoing to pinpoint genes responsible for hereditary breast and ovarian cancer.
  • Germline mutations in affected individuals will provide evidence for BRCA1 identity.

Conclusions:

  • The study is actively identifying and characterizing transcripts in the BRCA1 region.
  • This research is essential for understanding the genetic basis of early-onset breast and ovarian cancer.
  • Successful identification of BRCA1 will facilitate targeted therapies and risk screening.