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Epilepsy and intracranial meningiomas
1Department of Neurology, Taipei Municipal Yang-Ming Hospital, Taiwan, R.O.C.
Zhonghua Yi Xue Za Zhi = Chinese Medical Journal; Free China Ed
|February 1, 1995
Summary
Preoperative seizures in meningioma patients significantly predict postoperative seizures. Early management of cerebral edema, hemorrhage, and tumor recurrence is crucial for reducing seizure occurrence.
Area of Science:
- Neurosurgery
- Neurology
- Oncology
Background:
- Limited data exists on preoperative and postoperative seizure incidence in meningioma patients.
- This study investigates epilepsy incidence and causes in meningioma cases.
Purpose of the Study:
- To determine the incidence and types of preoperative epilepsy in meningioma patients.
- To identify predisposing factors for postoperative epilepsy following meningioma surgery.
Main Methods:
- Analysis of 323 surgically treated intracranial meningioma patients.
- Evaluation of seizure types, tumor locations, onset, and histopathological features.
Main Results:
- 30.3% of patients had preoperative epilepsy; 32.7% of these experienced persistent seizures postoperatively.
- 17.3% of patients without preoperative seizures developed them postoperatively, indicating a significant predictive value (p < 0.005).
- Cerebral edema and hemorrhage were early postoperative seizure causes; tumor recurrence was a late cause. Sagittal and convexity meningiomas showed higher seizure incidence.
Conclusions:
- A history of preoperative seizures is a significant predictor of postoperative seizures in meningioma patients.
- Surgical factors like hemorrhage/edema absence and anticonvulsant therapy can reduce postoperative seizures.