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Postprandial alkaline tide: does it exist?

C D Johnson1, D R Mole, A Pestridge

  • 1University Surgical Unit, Southampton General Hospital, UK.

Digestion
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

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Researchers investigated if changes in kidney and breathing function could measure stomach acid. They found no significant link between urine acid output or respiratory function and gastric acid secretion after meals.

Area of Science:

  • Physiology
  • Gastroenterology

Background:

  • The alkaline tide concept suggests renal and respiratory changes may indirectly reflect gastric acid secretion.
  • Investigating these physiological responses could offer a non-invasive method for assessing gastric function.

Purpose of the Study:

  • To determine if postprandial (after meal) changes in renal and respiratory function can be used to assess gastric acid secretion in healthy adults.

Main Methods:

  • Healthy volunteers consumed low, medium, or high protein meals on separate occasions.
  • Urine acid output was measured, and respiratory function parameters were assessed after meals.
  • Pharmacological interventions (ranitidine, omeprazole) were used in separate studies.

Main Results:

Related Experiment Videos

  • A decrease in urine acid output was observed after high-protein meals, but not medium or low-protein meals, and also in fasting states.
  • Ranitidine did not affect basal or postprandial urine acid output.
  • Omeprazole did not alter postprandial respiratory function, including ventilation, CO2 levels, or blood gas parameters.

    • Conclusions:

    • Changes in urine acid output are not reliably related to the gastric secretory response to food.
    • A significant respiratory alkaline tide could not be detected after a standard meal.
    • The study suggests that any urinary or respiratory compensation for gastric acid secretion is physiologically and clinically insignificant.