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Related Experiment Videos

Piroxicam-beta-cyclodextrin in induced migraine attacks: a SPECT study with Tc-99m HM-PAO split-dose method

M Trucco1, C Cananzi, P R Salvadori

  • 1Department of Neurology, Santa Corona Hospital, Pietra Ligure, Italy.

Functional Neurology
|September 1, 1994
PubMed
Summary

Piroxicam-beta-cyclodextrin (P-B-CD) relieved migraine pain and normalized regional cerebral blood flow (rCBF) abnormalities in patients. This non-steroidal anti-inflammatory drug effectively improved brain perfusion during migraine attacks.

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Area of Science:

  • Neurology
  • Pharmacology
  • Medical Imaging

Background:

  • Migraine attacks are often associated with alterations in regional cerebral blood flow (rCBF).
  • Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used for pain relief, but their effects on cerebral hemodynamics during migraine are not fully understood.

Purpose of the Study:

  • To investigate the efficacy of piroxicam-beta-cyclodextrin (P-B-CD), a novel NSAID, in alleviating migraine pain.
  • To assess the impact of P-B-CD on regional cerebral blood flow (rCBF) during migraine attacks using Single Photon Emission Computerized Tomography (SPECT).

Main Methods:

  • A study involving 7 female migraine patients (without aura) who experienced induced migraine-like attacks via sublingual nitroglycerin (NTG).
  • rCBF was evaluated using SPECT (Tc-99m examethyl-propylene-amino-oxyma) before and after oral administration of P-B-CD (20 mg).

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  • Pain intensity was assessed using direct and indirect parameters. Control subjects underwent similar NTG testing.

    • Main Results:

    • All patients reported significant pain relief following P-B-CD administration.
    • SPECT imaging showed normalization of previously detected symmetrical parietal or parieto-occipital areas of decreased tracer uptake in 3 patients after P-B-CD intake.
    • In 5 out of 8 patients, SPECT revealed a uniform and symmetrical radiocompound distribution, suggesting improved cerebral perfusion.

    Conclusions:

    • P-B-CD demonstrates effectiveness in relieving migraine pain.
    • This novel NSAID can reverse abnormal regional cerebral blood flow patterns observed during migraine attacks, indicating a potential therapeutic benefit beyond pain management.