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[Target dose markers. Exposure indicators for environmental epidemiological studies]

E Dybing1, J Alexander

  • 1Avdeling for miljømedisin Statens Institutt for Folkehelse, Oslo.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|April 20, 1995
PubMed
Summary

Accurate exposure assessment in environmental epidemiology is crucial. Target dose markers, like DNA and protein adducts, offer the best health outcome correlation but have limitations.

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Area of Science:

  • Environmental Epidemiology
  • Biomonitoring
  • Toxicology

Context:

  • Characterizing individual exposures is vital for environmental epidemiological studies.
  • Biologically effective dose (target dose) provides the strongest correlation with health outcomes.
  • Exposure markers are increasingly used to quantify internal dose.

Purpose:

  • To provide an overview of exposure markers used in environmental epidemiology.
  • To highlight the application and importance of target dose markers.
  • To discuss the limitations of current exposure assessment methods.

Summary:

  • Target dose markers, such as adducts to DNA and proteins, are valuable for assessing individual exposure in environmental epidemiology.
  • These markers quantify the dose at the site of action, improving the correlation with health outcomes.

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  • The review focuses on studies employing target dose markers and acknowledges their inherent limitations.

    • Impact:

    • Improved understanding of dose-response relationships in environmental health.
    • Enhanced accuracy in epidemiological studies assessing environmental exposures.
    • Guidance for researchers on selecting and interpreting exposure biomarkers.