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Related Experiment Videos

Time-domain ultrasonic contrast blood flowmetry

K K Shung1, R R Flenniken

  • 1Bioengineering Program, Pennsylvania State University, University Park 16802, USA.

Ultrasound in Medicine & Biology
|January 1, 1995
PubMed
Summary

High frame rate ultrasound and contrast agents improve blood flow estimation by addressing signal-to-noise and velocity limitations inherent in traditional methods.

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Area of Science:

  • Medical Imaging
  • Ultrasound Technology
  • Biomedical Engineering

Background:

  • Time-domain ultrasonic methods offer improved spatial resolution and angle independence compared to Doppler methods for blood flow estimation.
  • Conventional time-domain methods face challenges with low signal-to-noise ratio (SNR) due to weak blood echoes.
  • Velocity estimation in conventional methods is limited by the frame rate of ultrasound scanners.

Purpose of the Study:

  • To investigate the potential of high frame rate ultrasound in conjunction with ultrasonic contrast agents to overcome limitations in time-domain blood flow estimation.
  • To evaluate the effectiveness of Albunex as a contrast agent in enhancing blood flow signal.
  • To demonstrate improvements in SNR and maximal velocity estimation.

Main Methods:

  • Experimental evaluation of time-domain ultrasonic blood flow estimation.
  • Utilizing a high frame rate ultrasound scanner.
  • Administration of an ultrasonic contrast agent (Albunex) to enhance blood echoes.
  • Analysis of signal-to-noise ratio and maximal velocity estimation capabilities.

Main Results:

  • High frame rate ultrasound combined with Albunex contrast agent significantly improved signal-to-noise ratio in blood flow estimation.
  • The combined approach demonstrated an increased capacity for estimating higher velocities compared to conventional methods.
  • Experimental results confirmed the alleviation of intrinsic problems associated with time-domain ultrasonic flow estimation.

Conclusions:

  • High frame rate ultrasound imaging coupled with contrast agent injection is a promising strategy to enhance blood flow estimation.
  • This approach effectively addresses the limitations of poor SNR and restricted velocity measurement in conventional time-domain ultrasound.
  • The use of Albunex demonstrated its utility in improving the performance of these advanced ultrasonic techniques.

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