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A case with dicentric translocation between chromosome 9 and 18: confirmation by fluorescent in situ hybridization on
K Isoyama1, M Imai, A Ishikawa
1Department of Pediatrics, Showa University Fujigaoka Hospital, Yokohama, Japan.
Acta Paediatrica Japonica : Overseas Edition
|February 1, 1995
Abstract:
A female child with dicentric translocation between chromosome 9 and chromosome 18 presented non-specific minor anomalies with laryngomalacia. Chromosomal analyses were performed by the G-banding method and a fluorescence in situ hybridization (FISH) technique with a specific probe for the centromeric region of chromosome 18 and the painting probe for the chromosomes 9 and 18. Her full karyotype was confirmed as 45,XX,tdic(9;18)(p24;p11). This is the first case of dicentric translocation between chromosomes 9 and 18. The FISH technique is an important tool in chromosome diagnostics.