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Mutagenicity of dentin bonding agents
1University of Regensburg, Department of Operative Dentistry and Periodontology, Germany.
Journal of Biomedical Materials Research
|September 1, 1994
Summary
Syntac dental bonding agent demonstrated mutagenicity in bacterial tests, unlike Prisma Universal Bond and Pertac Universal Bond. Glutaraldehyde, a Syntac ingredient, also showed mutagenic effects, while other monomers did not.
Area of Science:
- Biomaterials Science
- Toxicology
- Dental Materials
Background:
- Limited data exists on the biological effects of dental bonding agents.
- Assessing the mutagenicity of dental materials is crucial for patient safety.
Purpose of the Study:
- To evaluate the mutagenic potential of three dental bonding agents and their components.
- To investigate the genotoxicity of Prisma Universal Bond, Pertac Universal Bond, and Syntac.
Main Methods:
- The Salmonella typhimurium mutagenicity test (Ames test) was employed.
- Five bacterial strains (TA97a, TA98, TA100, TA102, TA104) were used to assess mutagenicity.
- Eluates of bonding agents and ingredients in dimethyl sulfoxide and saline were tested.
Main Results:
- Prisma Universal Bond and Pertac Universal Bond showed no mutagenic effects.
- Syntac bonding agent exhibited significant mutagenicity in Salmonella typhimurium strain TA102.
- Glutaraldehyde, an ingredient in Syntac, was also found to be mutagenic.
Conclusions:
- Syntac dental bonding agent possesses mutagenic properties, potentially due to its glutaraldehyde content.
- Prisma Universal Bond and Pertac Universal Bond appear to be non-mutagenic.
- Further in vivo studies may be warranted to assess the clinical relevance of these findings.